During development of biological organisms, multiple complex structures are formed.In many instances, these structures need to exhibit a high degree of order to be functional, although many of their constituents are intrinsically stochastic.Hence, it has been suggested that biological robustness ultimately must rely on complex gene regulatory netwo
The availability of cost-efficient genotyping technologies has facilitated the implementation of genomic selection into numerous breeding programs.However, some studies reported a superiority of pedigree over genomic selection in line breeding, and as, aside from systematic record keeping, no additional costs are incurring in pedigree-based predict
As the most prevalent type of mRNA modification in mammals, N6-methyladenosine (m6A) is involved in various biological processes.Accumulating studies have indicated that the deregulation of m6A RNA modification is linked to cancer and other diseases.However, its implications in hepatocellular carcinoma (HCC) remain poorly characterized.Herein, we s
Incomplete ionization is an important issue when modeling silicon devices featuring aluminum-doped p+ (Al-p+) regions.Aluminum has a rather deep state in the band gap compared to boron or phosphorus, causing strong incomplete ionization.In this paper, we considerably improve our recent sepia plex parameterization [Steinkemper et al., J.Appl.Phys.11
Background: This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safety and efficacy.Methods: Immunogenicity was assessed during induction, upward titration, and mainten